Curriculum Vitae Dr. Antonio E. Alegria

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  EDUCATION

1973  B.S. Chemistry / University of Puerto Rico, Río Piedras, Puerto Rico
1976    Ph.D. Physical Chemistry / University of Puerto Rico, Río Piedras, Puerto Rico
1976-1977  Postdoctoral Phys. Org. Chemistry / Indiana State University
1987-1988 Postdoctoral Biophysics / NIH Bethesda, Maryland (collaboration with Dr. J. K. Kochi, 1976-77).

PROFESSIONAL POSITIONS

l977 to present Professor at the University of Puerto Rico 
1987-1988     Sabatical leave at NIH-NCI (research collaboration with Dr. Peter Riesz
1976-1977   Postdoctoral Research Associate at Indiana University 

IRESEARCH INTERESTS

Free radical mechanisms in photochemical, ultrasonic and redox systems with an emphasis in biological media. Electron Spin Resonance (ESR) spectroscopy as applied to studies of solution thermodynamics of anion radical systems. Spin-trapping and ESR spectroscopy as applied to the study of free radical intermediates.

  HONORS

1998     Igaravidez Award, ACS-Puerto Rico Chapter 
1997     Catedra Magistral, University of Puerto Rico-Humacao 
1997-present University of Puerto Rico Vicepresident’s Advisory Committee for the Assesment of  Research and Scholarly Activity 
l987-l988  NIGMS-MARC Faculty Development Fellow          
1986 to 1989 University of Puerto Rico President's Science Advisory Committee
l976-77     NSF Postdoctoral Research Fellow 
1973    Magna Cum Laude, B. S. Chemistry

PUBLICATIONS

"Heats of Solvation of Semiquinone-Sodium Ion Pairs in Hexamethylphosphoramide" A. E. Alegría, A. N. Medina, R. Tirado and F. Soto, J. Phys. Chem., 90, 5333 (l986)

 "Photochemistry of Aqueous Adriamycin and Daunomycin. A Spin Trapping Study with 17O Enriched Oxygen and Water." A. E. Alegría and P. Riesz, Photochem. Photobiol., 48, 147-152 (l988)

"Photochemistry of Aqueous Solutions of Benzazolo [3,2-a] quinolinium salts. A Spin Trapping Study using 17O-Enriched Water and Oxygen". A. E. Alegría, O. Cox, J. A. Dumas, L. A. Rivera and P. Riesz, Biochem. Biophys. Acta, 967, 1-10 (l988)

"An ESR Study of The Visible Light Photochemistry of Gilvocarcin V". A. E. Alegría, C. Murali Krishna, R. K. Elespuru and P. Riesz, Photochem. Photobiol., 49, 257-265 (l989)

"Sonolysis of Aqueous Surfactant Solutions. Probing the Interfacial Region of Cavitation Bubbles by Spin Trapping". A. E. Alegría, Y. Lion, T. Kondo and P. Riesz, J. Phys. Chem., 93, 4909-4913.

"Free Radicals Induced by Adriamycin-Sensitive and Resistant Tumor Cells: A Spin-Trapping Study". A. E. Alegría, A. Samuni, A. Russo, J. Mitchell and P. Riesz, Biochemistry, 28, 8653-8658 (1989).

"Thermodynamics of Disproportionation and Heats of Hydration of 1,4-Benzosemiquinone and 1,4-Naphtosemiquinone at pH 7.4" A. Alegría, C. Muñoz, and M. S. Rodríguez, J. Phys. Chem., 94, 930-934 (1990).

"Semiquinones Derived from Anthraquinone-Containing Antitumor Drugs Can Partition Into Lecithin Bilayers" A. E. Alegria, M. S. Rodriguez and J. Hernandez Biochim. Biophys. Acta, 1035, 51-55 (1990).

"Effect of Ion-pair Formation Between 1,4-Benzosemiquinone and Alkaline-earth Metal Cations on the Semiquinone Disporportionation Equilibrium at Physiological pH". A. E. Alegría, B. Velázquez, J. Sol. Chem., 21, 1241-1249 (1992)

"Reductive Activation of Benzazolo (3,2-alquinolinium Salts", A. E. Alegría, O. Cox, L. Zayas, L. A. Rivera, J. Dumas, Free Rad. Biol. Med., 15, 49-56 (1993)

"Electron Paramagnetic Resonance Studies of the Interaction of Semiquinone, Na+ Ion pairs with Phosphatidylcholine in Ethereal Solvents" A. E. Alegria, A. Moctezuma and B. Velazquez J. Chem. Soc., Faraday Trans., 89, 3363-3369 (1993)

"Membrane-buffer Partition Coefficients of Semiquinones using the Spin-broadening Technique" A. E. Alegria, S. Rivera, M. Hernandez, R. Ufret and M. Morales J. Chem. Soc., Faraday Trans., 89, 3773-3777 (1993).

"A Comparative Study of the Visible Light Photochemistry of Gilvocarcins V and M", A. E. Alegria, L. Zayas and N. Guevara, Photochem. Photobiol., 62, 400-415 (1995).

"Thermodynamics of Semiquinone Disproportionation in Aqueous Buffer", A. E. Alegria,M. Lopes and N. Guevara, J. Chem.Soc., Faraday Trans., 92, 4965-4968 (1996).

"Photophysical Properties of Gilvocarcins V and M and Their Binding Constant to Calf Thymus DNA", R. Oyola, R. Arce, C. Garcia and A. E. Alegria, Photochem. Photobiol., 65, 802-810 (1997).

"Adriamycin and Daunomycin Semiquinones Membrane/buffer Partition Constants Using the Spin-Broadening Technique", A.E. Alegria and G. Santiago, Arch. Biochem. Biophys.,346, 91-95 (1997).

"Photochemistry of Water-soluble Quinones. Production of a Water-derived Spin Adduct" A. E. Alegria, A. Ferrer and E. Sepulveda, Photochem. Photobiol., 66, 436-442 (1997).

"Structural and Hydrophylicity Requirements in Quinone-induced Lipid Peroxidation of Phosphatidylcholine Vesicles" A. E. Alegria and G. Santiago,Toxicol. Environ. Chem., 65, 185-202 (1998)

"The Photobiological Differences of Gilvocarcins V and M are Not Related to their Transient Intermediates and Triplet Yields." R. Oyola, R. Arce and A. E. Alegria, Photochem. Photobiol., 68, 25_31 (1998).

"Structural and Hydrophylicity Requirements in Quinone-induced Lipid Peroxidation of Phosphatidylcholine Vesicles" A. E. Alegria and G. Santiago, Toxicol. Environ. Chem., 65, 185-202 (1998).

" Electrochemical and Electron Spin Resonance Studies of Selected Benzazolo[3,2- a]quinolinium Salts"., O. Cox, J. A. Dumas, L. A. Rivera, C. García and A. E. Alegría, Heterocycl. Chem., 36, 943-947 (1999).

"Photochemistry of Water-soluble Quinones. Production of Hydroxyl Radical, Singlet Oxygen and the Superoxide Ion." A. E. Alegría, A. Ferrer, G. Santiago, E. Sepúlveda and W. Flores, J. Photochem. Photobiol. A-Chemistry, 127, 57-65 (1999).

"Sonochemistry of Quinones in Argon-Saturated Aqueous Solutions: Enhanced Cytochrome c Reduction". R. C. Lawson, A. Ferrer, W. Flores and A. E. Alegría, Chem. Res. Toxicol., 12, 850-854 (1999).

"Intramolecular hydrogen bonding in hydroxylated semiquinones inhibits semiquinone-Mg2+ complex formation" A. E. Alegria, C. Garcia, G. Santiago, G. Collazo and J. Morant, J. Chem Soc., Perkin Trans. 2, 1569-1573 (2000).

"Reductive Activation of Terpenylnapthoquinones". A.E. Alegría, Emelyn Cordones, Glysette Santiago, María Gordaliza, María L.
Martín Martín, Toxicology 2002. P. 167-175.

"Role of Membrane charge and semiquinone structure on oxygen consumption rates". A.E. Alegría, Emelyn Cordones,Veronica Castro, Lizmarie Rivera and Pedro Sánchez.  Perkin P1823. (October 2002).

"Reductive Activation and thiol reactivity of benzazolo [3,2-a] quinolinium salts"
Antonio E. Alegría, Wilmarie Flores, Emelyn Cordones, Lizmarie Rivera,  Pedro L. Sánchez, Marisol Cordero, Osvaldo Cox.  Elsevier, Toxicology 2004 (87-96)

Sonochemistry  of antitumor quinones in argon-saturated aqueous solutions: enhanced ferrycytochrome c reduction" .  Dalia López, Antonio E. Alegría.  Elsevier  Ultrasonics Sonochemistry (2004) 311-316.