Curriculum Vitae Dra. Margarita ortiz

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EDUCATION

1968 B. S.: Chemistry, Universidad Nacional de Colombia
1973 M. S.: Physical Organic Chemistry, U. of Alabama, Huntsville
1979 Ph. D.: Organic Chemistry, University of Alabama, Tuscaloosa,
1980-81 Post Doctoral Research: University of Puerto Rico

RESEARCH INTEREST

Organic Synthesis via Organometallic Reagents, Enantioselective Synthesis, New Methods for the the Synthesis of Amines with Stereochemical Control, and Heterocyclic Chemistry.

ADMINISTRATIVE EXPERIENCE

1987-1988 MBRS Project Director at the HUC 
1986 to 1994 NIH-MHSSRAP - Project Director at the HUC 
1982-1986 Coordinator of the Organic Chemistry Courses 
1984-1991 Coordinator of the Program of Practice in the Industry 

ADVISORY COMMITTEES

1989-1994 Scientific Committee of the Industry-University Research Center (NSF-UPR-INDUNIV)
May 1990 NIH-MBRS Study Section, Maryland
May 1994 NIH-MBRS Study Section, Maryland
1989-present MBRS Advisory Committee, UPR-Humacao
1991-1996 MARC Advisory Committee, UPR-Humacao
1990-1993 UPR-Humacao Honor Program

RESEARCH GRANTS

1986-1988 UPR-Humacao,  Synthesis of Amines, $7,000.00
1986-87
NSF-Resource Center for Science and Engineering of the University of Puerto Rico,  New Alternatives for the Synthesis of Primary Amines with Stereochemical Control, $10,000.00.
1987
NIH-MBRS (Instrumentation Program),  "Acquisition of an GC/MS Spectrometer" $95,000, Co-PI.
1987-1990
NIH-MBRS-Supplemental Application, "New Methodology for the Stereochemical Controlled Synthesis of Biological Active Amines", $111,032.
1990-1994
NIH-MBRS-), New Methodology for the Stereochemical Controlled Synthesis of Biological Active Amines", $172,789.
1994-1998
NIH-MBRS-, Stereocontrolled Synthesis of Biological Active Amines", $278,000.
1999-2003
NIH-MBRS-, Stereoselective Synthesis of Primary Amines, Amino Alcohols and Amino Acids".
1999-2002
NIH-AREA-, Synthe
sis of Biological Active Amines and Aminoalcohols.

PROFESSIONAL ASSOCIATIONS

American Chemical Society - Organic and Medicinal Chemistry Sections (!973-date).

Sigma Xi-Research Society (1973-1984).

National Education Association (1983-date).

Asociación de Maestros de Puerto Rico (1983-date).

PUBLICATIONS

Studies of the Catalyzed Reaction between Alcohols and Alkyl Isocyanates, P. McManus, H. S. Bruner, H. D. Coble and M. Ortiz, J. Org. Chem., 1977, 42, 1428.

The Cycloaddition Reaction of Sulfonyl Azides with Dienes, R. A. Abramovitch, M. Ortiz and S. P. McManus, J. Org. Chem., 1981, 46, 330.

The Reaction of Sulfonyl Azides with Alkylidenecycloalkanes. Steric and Electronic Effects, M. Ortiz, S. P. McManus and R. A. Abramovitch, J. Org. Chem., 1981, 46, 336.

The Reaction of Trimethylsilyl Esters with Metal Hydride Reducing Agents. Protection of Carboxylic Acid as their Trimethylsilyl Esters during Hydroboration, G. L. Larson, M. Ortiz and M. Rodríguez de Roca, Synthetic Commun., 1981, 11, 583.

The Reaction of Aromatic Sulfonyl Azides with Trialkylboranes, M. Ortiz and G. L. Larson, Synthetic Commun., 1982, 12, 43.

A Convenient Method for the Synthesis of O-t-Butyldimethylsilyl Oximes, M. Ortiz, J. F. Cordero, S. Pinto and I. Alverio, Synthetic Comm, 1994, 24, 409.

The Reduction of (O-tert-Butyldimethylsilyl) Aldoximes and Ketoximes and Electronic Effects Studies on the Novel Rearrengement that occurs with a Borane-THF Complex, M. Ortiz-Marciales, E. Cruz, I. Alverio, D. Figueroa, J. F. Cordero, J. Morales, J. A. Soto, H. Dashmana and C. Burgos, J. Chem. Res.(S) 1998, 10; (M) 0151.

New Method for the Synthesis of Nitriles via the (O-tert-Butyldimethylsilyl) Aldoximes, M. Ortiz-Marciales, L.Piñero, L. Ufret, W. Algarin and J. Morales, Synthetic Comm.1998, 28.

N-tert-Butyldimethylsilylimines as Intermediaries for the Synthesis of Amines and Ketones M. Ortiz-Marciales, L. M. Tirado, R. Colón, M. L. Ufret, R. Figueroa, M. Lebrón, M. DeJesús, J. Martínez and T. Malavé, Synthetic Comm., 1998, 28, 4067.

The "Alkylation of (O-tert-Butyldimethylsilyl) Ketoximes M. Ortiz, M. DeJesús, L. Quiñones, D. Fiqueroa, Y. Montes, C. Burgos, and B. Moctezuma, Tetrahedron 1999, 55, 12275.

Steric and Electronic Effects on the Reduction of O_Silylated Aromatic Ketoximes with Borane, Ortiz-Marciales, Margarita; Figueroa, Dyliana; De Jesús, Melvin; Frett, José A.; Vega, Rafael,. Tetrahedron Letters 2000, 41, 6567.

PRESENTATIONS

Margarita Ortiz, Orlando Conde, Maritza Gómez and Carlos Pérez, The Synthesis and Reactions of N-Silyl, N-Silyloxy- and N-Acylimines, Third Chemical Congress of North America, Toronto, Canada, June 6, 1988.

Margarita Ortiz, José F. Cordero, Synthesis of N-tert-Butyldimethyl Silyl Oximes, XII ACS, Senior Technical Meeting, San Juan, Puerto Rico, November 19, 1988.

Margarita Ortiz, Orlando Conde, José F. Cordero, Synthesis and Reactions of N-Silyloxi-and N-Acylimines", 3th Humacao College Research Day, Humacao, Puerto Rico, April 26, 1989.

Margarita Ortiz, José F. Cordero, Synthesis and Reduction of O-Silyloximes", The National Meeting of the American Chemical Society (ACS), April, 1989, Boston.

Margarita Ortiz, José F. Cordero, Fragmentation of O-tert-Butyldimethylsilyl Aldoximes to Produce Nitriles, 2nd Panamerican Congress, September 25, 1991, San Juan P.R.

Margarita Ortiz, María de Lourdes Ufret, Elmer Cruz, Deborah Nieves, Elba Arroyo, Fragmentation of O-tert-Butyldimethylsilyl Aldoximes to Produce Nitriles, National Meeting of the American Chemical Society, April 7, 1992, San Francisco.

Margarita Ortiz, Elmer Cruz, Ileana Alverio, Reduction of O-tert-Butyldimethylsilyl Oximes, 206th National Meeting of the American Chemical Society, August 22, 1993, Chicago.

M. Ortiz, J. Soto, J. Morales, C. Burgos; The Reductive Rearrangement of O-tert-Butyldimethylsilyl Oximes with BoraneCTHF Complex, 209th National Meeting of the American Chemical Society, April 5, 1995, Anaheim.

M. Ortiz, L. M. Tirado, R. Colón, R. Reyes and T. Malavé, N-tert-Butyldimethylsilyl Imines as Intermediates for the Synthesis of Ketones and Primary Amines, 211th ACS National Meeting, March 27, 1996, New Orleans, LA.

M. Ortiz, Síntesis de Aminas Primarias Quirales, conference to Department of Chemistry, Centro de Investigaciones Avanzadas del Instituto Politécnico de México, México D.F., March 6, 1998.

M. Ortiz, L. Quiñones, M. DeJesús, C. Burgos, D. Fiqueroa, L. Vázquez, J. A. López and B. Moctezuma, "The "-Alkylation of O-tert-Butyldimethylsilyl Ketoximes", XXIII Congreso Latinoamericano de Química, July 1998, Río Mar, PR.

M. Ortiz, L. Quiñones, M. DeJesús, C. Burgos, D. Fiqueroa, L. Vázquez, J. A. López and B. Moctezuma, "The "-Alkylation of O-tert-Butyldimethylsilyl Ketoximes", 216th ACS National Meeting, August 23-27, 1998, Boston, MA.

M. Ortiz-Marciales, M. DeJesús, Fiqueroa Synthesis of Primary Aminess and Anilines, NSF-CIRE-PUMP, December 7, 1999, UPR-Humacao, PR.

Margarita Ortiz-Marciales, Dyliana Figueroa and José A. López. Steric and Electronic Effects on the Borane Reduction of O-Silylated Aromatic Ketoxime, 219 th National Meeting of the American Chemical Society, March 27, 2000, San Francisco,CA.