Curriculum Vitae Dr. Carmelo García

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HONORS

1972-1977 Honor registration at the University of Puerto Rico
1973   HUC Medal in Chemistry and Physics
1973-1974 "Who is Who"- Certification
1974 Magna Cum Laude (Assoc. Degree - Natural Sciences)
1976     Magna Cum Laude (B.S. Chemistry)
1982  Magna Cum Laude (Ph.D. Physical Chemistry
1987   UPR Recognition for Academic Excellence and Productivity
1999 UPR Recognition for Academic Excellence and Productivity

 

DOCTORAL THESIS  

"Photochemical Investigations on Model-Compounds of Epoxy-Resins" (Advisor: Prof. Dr. H.-J. Timpe)

PhD AND POST. DOC  

TRAINING Photochemistry, Quantum Chemistry and Laser Photomedicine

LANGUAGES - Spanish, English and German

PROFESSIONAL POSITIONS

1979-1980 Research Assistant for Photochemistry at the TH-"Carl Schorlemmer", Merseburg, DDR
1982-1984 Post-doctoral Research on Quantum-Chemical Calculations on the butadiene photochemical reaction at the FU-Berlin, West Germany (Under supervision of V.Bonaci…-Kouteckí)
1984-1987 Assistant Professor at the Department of Chemistry at the Humacao University College, Humacao (PR).
1987-1984 Associate professor at the Humacao University College (Humacao PR)
1984 to present Full professor at the Humacao University College
1990-1992 Visiting Associate Professor at the Harvard Medical School (Boston, MA)
1990 to present Visiting Chemist at Massachusetts General Hospital (Boston, MA)

 TEACHING EXPERIENCE

Chemistry 3001-3002 General Chemistry
Chemistry 4041-4042 Physical Chemistry
Chemistry 4051-4052 Intermediate Lab of Physical Chemistry
Chemistry 3003-3004 Lab of General Chemistry
Chemistry 3161-3013 Bio Chemistry for the Health Sciences
Physic 1011 Introductory Physics for Technicians
Chemistry 4205 Photochemistry
PREH 4701 Mathematical Methods for Physical Chemistry
TEQU 2005 Applied Programming for Chemists
Chemical Technology Introductory Chemistry for Technicians

RESEARCH INTERESTS

Photochemistry of aromatic ethers, Photochemistry of epoxides, Photochemistry of aromatic amines, Laser Flash photolysis, Photosynthesis of amino-epoxy-polymers, Quantum Chemical calculations of spectral parameters, Quantum Chemical calculations of atomic parameters in the momentum space with Breit-Pauli-type hamiltonians, Laser Spectroscopy, Laser Photomedicine, Steady State and Lifetime Fluorescence

SUPERVISORY EXPERIENCE

Supervision of the research efforts of two undergraduate students at the TH-"Carl Schorlemmer" (1980-1981) and two undergraduate students at University of Puerto Rico at Humacao (1986-1990)

Supervision of a 6 member research group at UPR-Humacao as part of an NIH-MBRS proposal (1994-present)

AWARDED GRANTS

Photoproduction of amino-epoxy-polymers. Resource Center for Science and Engineering. UPR (1984) $5,000

Quantum chemical calculations on aromatic amines. Dean of Studies HUC (1985) $3,800Photoproduction of amino-epoxy-polymers. Resource center for Science and Engineering. UPR (1985) $5,000

Atomic energies calculations in the momentum space (In collaboration with Dr. R. Baretty, Department of Physics, Humacao University College) Dean of Studies HUC (1987) $5,000

Phototoxicity of some phenothiazine drugs studied in vitro with Nd-YAG Lasers (under the supervision of Prof. Dr. Irene E. Kochevar, Harvard Medical School; NIH (1990 -1993) $180,000

Synthesis and Laser Flash Photolysis of novel promazine derivatives; NIH - MBRS (1984-1988) $260,000

MBRS Supplemental proposal for the acquisition of a SPEX fluorolog Tau2 spectrofluorimeter (1996) $110,000

MBRS administrative supplemental proposal for the acquisition of a preparative HPLC system (1996) $22,000

Photophysical and Photochemical Properties of Neuroleptic Drugs; NIH-MBRS (1999-2002) $367,000

PUBLICATIONS

"Photochemische Untersuchungen an Epoxidharz- Modellverbindungen"; H.-J. Timpe, C. García, M. Fedtke; Z. Chem. 21, 38 (1981)

"Modelluntersuchungen zur Lichtstabilität von Epoxidharzen"; H.-J. Timpe, C. García, M. Fedtke; 7. Hochpolymerentagung Leipzig, DDR (1981)

"Photochemische Untesuchungen an Expoxidharz-Modellverbindungen"; Ph. D. Thesis THLM - "Carl Schorlemmer" DDR (1982)

"Ein neues Darstellungsverfahren für o-Hydroxy-propiophenone durch Reaktion von o-Allyl-phenolen mit Perbensoesäure"; H.-J. Timpe, C. García, E. Kunstermann; Z. Chem. 23, 52 (1983)

"Abhängigkeit der Quantenausbeute von molekularen Parametern bei der Photo-Claisen-Umlagerung aromatischer Ether"; H.-J. Timpe, C. García, H. Bögel, E. Bauwe; Z. Physik. Chem. (Leipzig) 264(2), 329 (1983)

"Photochemical and Photophysical Investigations on Bisphenol-A-Epichlorohydrin condensation polymers and Model compounds"; H.-J. Timpe, C. García, S. P. Pappas, L. R. Breskman, R. M. Fischer; Polymer Photochem. 6, 41 (1985)

"Photochemische Addition von Phenolen an Phenylglycid-ether"; H.-J. Timpe, C. García, M. Fedtke; Z. Chem., 24(5), 186 (1984)

"Photochemische Reaktionen von Arylglycidethern"; H.-J. Timpe, C. García, M. Fedtke; J. Prakt. Chem., 327(4), 616 (1985)

"Modified Breit-Pauli hamiltonian suitable for variational calculations"; R. Barrety, C. García; Int. J. Quantum Chem. 22, 425 (1988)

"Atomic energies calculations with a one-parameter integral method"; R. Barrety, C. García; J. Chem. Educ. 66(1), 45 (1989)

"Mechanism and solvent dependence for photoionization of promazine and chlorpromazine"; C. García, G. A. Smith, W. G. McGymsey, R. Redmond, I. E. Kochevar; J. Am. Chem. Soc. 117(44), 10871-10878 (1995)

"Photophysical properties of gilvocalcins V and M and their binding to calf thymus DNA"; R. Oyola, R. Arce, A. E. Alegría, C. García; Photochem. Photobiol. 65, 802-810 (1997)

"Photoaddition to DNA by Nonintercalated chlorpromazine molecules"; I.E. Kochevar, C. García and N. Geacintov; Photochem. Photobiol. 68 692-697 (1998)

"Electrochemical and Electron Spin Resonance Studies of Selected Benzazolo[3,2-a]quinolinium Salts"; O. Cox, J. A. Dumas, L. A. Rivera, C. García and A. E. Alegría (1999); J. Heteroc. Chem. (in print)

"Intramolecular Hydrogen Bonding in Hydroxylated Semiquinones Inhibit Semiquinone-Mg2+ Complex Formation" Alegría, C. García, G. Santiago, G. Collazo and J. Morant; Biochem. Biophys. Acta, Submitted

"Photophysical, Electrochemical, and Theorical Study of Protriptyline in Several Solvents". Carmelo García, Rolando Oyola, Luis E. Piñero, Nadya Cruz, Felix Alejandro, Rafael Arce and Ileana Nieves. J Phys Chem B 2002, 106, 9794-9801.

"Photophysical and Photochemical properties of amitriptyline and nortriptyline hydrochloride: a 266 nm nanosecond laser flash and theorical study" Rafael Arce, Carmelo García, Rolando Oyola, Luis E. Piñero, Ileana Nieves, Nadya Cruz.  J of Photochemistry and Photobiology A: Chemistry 154 (2003) 245-257.

PRESENTATIONS

C. García, R. W. Redmond, I. E. Kochevar; Structure-Activity analysis of the photochemistry of phenothiazine drugs; Third Pan-American Chemical Congress; San Juan, PR (SEP-1995)

C. García, J. Suárez, S. Amaro, D. Maralet, P. Lugo-Mas; Synthesis of Novel Promazine Derivatives; 19th ACS - Senior Technical Meeting, Lajas, PR (NOV-1995)

C. García, I. E. Kochevar; Fluorescence determination of binding constants for guest- host systems with two different types of complexes; 212th ACS National Meeting; Orlando, Florida (AUG-1996)

S. A. Bargouthi, K. Lawler, C. García; Spectrophotometric studies of catacondensed aromatic hydrocarbons; 212th ACS National Meeting; Orlando, Florida (AUG-1996)

C. García, J. Suárez, S. Amaro, D. Maralet, P. Lugo-Mas; Synthesis of Novel Promazine Drugs; NIGMS - Research Symposium; Washington, DC (1995)

L. Piñero, C. García, J. Suárez; Síntesis de bifenil-aminas meta substituidas; 31th. ACS Junior Technical Meeting; UPR-Arecibo, PR (MAR-1996)

P. Lugo-Mas, E. Salas, C. García, J. Suárez; Síntesis de Derivados de Promazina I; 31th. ACS Junior Technical Meeting; UPR-Arecibo, PR (MAR-1996)

S. Amaro, E. Román, C. García, J. Suárez; Síntesis de Derivados de Promazina II; 31th. ACS Junior Technical Meeting; UPR-Arecibo, PR (MAR-1996)

C. García, J. Suárez, L. Piñero, D. Maralet, P. Lugo-Mas, S. Amaro; Synthesis of Novel Promazine Derivative: Thionation vs The Smiles’ Rearrangement; 212th ACS National Meeting; Orlando, Florida (AUG-1996)

C. García, L. E. Piñero, C. Mateo, D. Maralet; Steric Effects on the Synthesis of Promazine Derivatives; 213th ACS National Meeting, San Francisco, CA (APR-1997)

Y. Abreu, C. García and L. E. Piñero; Steric Control of the Formation of Phenothiazines; NIGMS - National Minority Programs Symposium; New Orleans, Louisiana (OCT-1997)

P. Lugo-Mas, C. García, L.E. Piñero, S. Amaro, A. Morales; Geometry Control of the Formation of Promazines by Thionation; The 5th Chemical Congress of North America; Cancún, MX (NOV-1997)

J. García, C. García, L. Piñero; Geometry Control of the Smiles Phenothiazine Synthesis; The Fifth Chemical Congress of North America , Cancún Mexico (NOV-1997)

R. Oyola, R. Arce, C. García; Photophysical Properties of Phenothiazine Derivatives, The Fifth Chemical Congress of North America , Cancún Mexico (NOV-1997)

C. García; Photophysics of Promazine Drugs; MOVA Pharmaceutical Industry, Caguas PR, ACS-Chemistry Week (NOV-1997)

Yamilka Abreu, Lisandra Negrón, Luis E. Piñero, Angel Morales and Carmelo García; New Method to Synthesize Promazine Derivatives: Bioactive Molecules in the Treatment of Psychiatric Illness; ACS national Meeting; Anaheim, CA (MAR-1999)

Luis E. Piñero y Carmelo García; Control Cinético En La Síntesis De Fenotiazinas; XXIII Congreso FLAQ Rio Grande, Puerto Rico (JUL-1998)

Piñero Luis E., Morales Angel, Negrón Lisandra, Abreu Yamilka and García Carmelo; New Method to Synthesize Promazine Derivatives: Bioactive Molecules in the Treatment of Psychiatric Illness; The 1998 National Minority Research Symposium New York, New York (NOV-1998)

Yamilka Abreu, Carmelo García, Luis E. Piñero Y Angel Morales; Control Estérico En La Formación de Fenotiazinas; 33rd ACS Junior Technical Meeting; Bayamón, Puerto Rico (MAR-1998)

Ángel Morales, Yamilka Abreu, Lisandra Negrón, Luis E. Piñero y Carmelo García; Síntesis De Fenotiazinas Por Inserción De Nitrenos; 34th ACS Junior Technical Meeting and 19th Puerto Rico Interdisciplinary Scientific Meeting; Mayaguez, Puerto Rico (MAR-1999)

Carmelo García, Luis E. Piñero and Angel Morales; Photosynthesis of Promazines: Bioactive Molecules in the Treatment of Psychiatric Illness, XIX International IUPAC Photochemistry Conference; Durham, NC (AUG-1999)